Article
Structure-function analysis of human stomatin: A mutation study.
PloS one - 1 Jan 2017
Rungaldier Stefanie, Umlauf Ellen, Mairhofer Mario, Salzer Ulrich, Thiele Christoph, Prohaska Rainer
Abstract excerpt
Stomatin is an ancient, widely expressed, oligomeric, monotopic membrane protein that is associated with cholesterol-rich membranes/lipid rafts. It is part of the SPFH superfamily including stomatin-like proteins, prohibitins, flotillin/reggie proteins, bacterial HflK/C proteins and erlins. Biochemical features such as palmitoylation, oligomerization, and hydrophobic "hairpin" structure show similarity to...
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