Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics.

doi:10.1161/CIRCRESAHA.119.315715

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Article

Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics.

Circulation research - 8 Jan 2021

Gross Polina, Johnson Jaslyn, Romero Carlos M, Eaton Deborah M, Poulet Claire, Sanchez-Alonso Jose, Lucarelli Carla, Ross Jean, Gibb Andrew A, Garbincius Joanne F, Lambert Jonathan, Varol Erdem, Yang Yijun, Wallner Markus, Feldsott Eric A, Kubo Hajime, Berretta Remus M, Yu Daohai, Rizzo Victor, Elrod John, Sabri Abdelkarim, Gorelik Julia, Chen Xiongwen, Houser Steven R

Abstract excerpt

RATIONALE: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) and RyR (ryanodine receptors) within the junctional sarcoplasmic reticulum. CICR is disrupted in cardiac hypertrophy and heart failure, which is associated with loss of T-tubules and disruption of cardiac dyads. In these conditions, LTCCs are...

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Identifiers

PMID: 33092464
DOI: 10.1161/CIRCRESAHA.119.315715
PMCID: PMC7790862

Genes

JPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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