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Article

The emerging role of alternative splicing in senescence and aging

13 Jul 2017

Abstract excerpt

Deregulation of precursor mRNA splicing is associated with many illnesses and has been linked to age-related chronic diseases. Here we review recent progress documenting how defects in the machinery that performs intron removal and controls splice site selection contribute to cellular senescence and organismal aging. We discuss the functional association linking p53, IGF-1, SIRT1, and ING-1 splice variants with...

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PMID: 28703423
DOI: 10.1111/acel.12646

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