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Article

Alternative splicing in aging and longevity.

Human genetics - 1 Mar 2020

Bhadra Malini, Howell Porsha, Dutta Sneha, Heintz Caroline, Mair William B

Abstract excerpt

Alternative pre-mRNA splicing increases the complexity of the proteome that can be generated from the available genomic coding sequences. Dysregulation of the splicing process has been implicated in a vast repertoire of diseases. However, splicing has recently been linked to both the aging process itself and pro-longevity interventions. This review focuses on recent research towards defining RNA splicing as a new...

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Identifiers

PMID: 31834493
DOI: 10.1007/s00439-019-02094-6
PMCID: PMC8176884

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