Article

Integrative analyses of splicing in the aging brain: role in susceptibility to Alzheimer’s Disease

2017-08-10

Abstract excerpt

<h4>ABSTRACT</h4> We use deep sequencing to identify sources of variation in mRNA splicing in the dorsolateral prefrontal cortex (DLFPC) of 450 subjects from two prospective cohort studies of aging. Hundreds of aberrant pre-mRNA splicing events are reproducibly associated with Alzheimer’s Disease (AD). We also generate a catalog of splicing quantitative trait loci (sQTL) effects in the human cortex: splicing of 3...

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Literature Corpus work: 03a1f2bf-e832-5cd0-98ed-6d61ecda4a8b
DOI: 10.1101/174565

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