Article

Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing

2022-03-14

Abstract excerpt

Adult aging is characterized by a progressive deterioration of biological functions at physiological, cellular and molecular levels, but its damaging effects on the transcriptome are not well characterized. Here, by analyzing splicing patterns in ∼1,000 human subjects sampled across multiple tissues, we found that splicing fidelity declines with age. Most prominently, genuine introns fail to be spliced out, manife...

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Literature Corpus work: 6c3bfbc2-552f-56b4-a74a-51589f786bc4
DOI: 10.1101/2022.03.14.484341

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