Article

Heritable Susceptibility for Colitis in Mice Induced by IL-10 Deficiency

2000-11-01

Abstract excerpt

Severity of inflammatory bowel disease in IL-10 gene-targeted mice is in part determined by genetic background. In the current study, a targeted IL-10 gene was transferred into the C3H/HeJBir substrain, known to exhibit high T-cell and B-cell responses to enteric flora, and to be highly sensitive to colitigenic stress. IL-10-deficient C3H/HeJBir mice developed early onset colitis in contrast to IL-10-deficient C57...

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Literature Corpus work: 5e3f366e-1a51-597f-b1d8-fa442f2f825c
DOI: 10.1097/00054725-200011000-00006

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