Article
Heritable susceptibility for colitis in mice induced by IL-10 deficiency.
Inflammatory bowel diseases - 1 Nov 2000
Bristol I J, Farmer M A, Cong Y, Zheng X X, Strom T B, Elson C O, Sundberg J P, Leiter E H
Abstract excerpt
Severity of inflammatory bowel disease in IL-10 gene-targeted mice is in part determined by genetic background. In the current study, a targeted IL-10 gene was transferred into the C3H/HeJBir substrain, known to exhibit high T-cell and B-cell responses to enteric flora, and to be highly sensitive to colitigenic stress. IL-10-deficient C3H/HeJBir mice developed early onset colitis in contrast to IL-10-deficient...
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