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Article

Genetic background of IL-10(-/-) mice alters host-pathogen interactions with Campylobacter jejuni and influences disease phenotype.

Microbial pathogenesis - 1 Oct 2008

Mansfield L S, Patterson J S, Fierro B R, Murphy A J, Rathinam V A, Kopper J J, Barbu N I, Onifade T J, Bell J A

Abstract excerpt

We hypothesized that particular genetic backgrounds enhance rates of colonization, increase severity of enteritis, and allow for extraintestinal spread when inbred IL-10(-/-) mice are infected with pathogenic C. jejuni. Campylobacter jejuni stably colonized C57BL/6 and NOD mice, while congenic strains lacking IL-10 developed typhlocolitis following colonization that mimicked human campylobacteriosis. However,...

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Identifiers

PMID: 18586081
DOI: 10.1016/j.micpath.2008.05.010
PMCID: PMC4148907

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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