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Article

Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity.

Inflammatory bowel diseases - 1 May 2010

Bleich Andre, Büchler Gwen, Beckwith Jason, Petell Lydia M, Affourtit Jason P, King Benjamin L, Shaffer Daniel J, Roopenian Derry C, Hedrich Hans J, Sundberg John P, Leiter Edward H

Abstract excerpt

BACKGROUND: The cytokine-deficiency-induced colitis susceptibility (Cdcs)1 locus is a major modifier of murine inflammatory bowel disease (IBD) and was originally identified in experimental crosses of interleukin-10-deficient (Il10(-/-)) mice. Congenic mice, in which this locus was reciprocally transferred between IBD-susceptible C3H/HeJBir-Il10(-/-) and resistant C57BL/6J-Il10(-/-) mice, revealed that this locus...

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PMID: 19856416
DOI: 10.1002/ibd.21146
PMCID: PMC2857671

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