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Article

Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions

11 Jan 2012

Abstract excerpt

BACKGROUND: Colitis susceptibility in Il10(-/-) mice depends on genetic background and microbiota composition. A major genetic locus mediating colitis susceptibility, Cdcs1, was transferred from susceptible C3Bir-Il10(-/-) to resistant B6-Il10(-/-) mice, resulting in susceptible congenic BC-R3-Il10(-/-) mice. The aim of this study was to determine the impact of microbiota on this differential colitis...

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PMID: 22238116
DOI: 10.1002/ibd.21895

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