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Article

A Multihit Model: Colitis Lessons from the Interleukin-10-deficient Mouse.

Inflammatory bowel diseases - 1 Aug 2015

Keubler Lydia M, Buettner Manuela, Häger Christine, Bleich André

Abstract excerpt

Complex mechanisms are pulling the strings to initiate the development of inflammatory bowel disease. Current evidence indicates that an interaction of genetic susceptibilities (polymorphisms), environmental factors, and the host microbiota leads to a dysregulation of the mucosal immune system. In the past decades, the interleukin-10-deficient mouse has served as an excellent model to mirror the multifactorial...

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Colitis
Disease Models, Animal
Genetic Predisposition to Disease
Inflammatory Bowel Disease
Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopic Colitis

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PMID: 26164667
DOI: 10.1097/MIB.0000000000000468
PMCID: PMC4511684

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