Article
Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses.
Gastroenterology - 1 Aug 2002
Bouma Gerd, Kaushiva Anjali, Strober Warren
Abstract excerpt
BACKGROUND & AIMS: Immunogenetic analysis of experimental colitis may contribute to the further unraveling of the complex genetic basis of the inflammatory bowel diseases, Crohn's disease and ulcerative colitis. METHODS: Genetic regions associated with susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis were identified in a genome-wide linkage analysis in F2 progeny of colitis-susceptible SJL/J...
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