Article

Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

2025-02-01

Abstract excerpt

Among the extensive genomic alterations in prostate cancer, the genomic deletion of PTEN stands out as one of the most consistently observed and confirmed alteration. PTEN loss in prostate tumors is primarily associated with cancer cell proliferation and survival through the activation of the PI3K-AKT-mTOR signalling pathway. However, its use as a robust biomarker in the clinical practice is hampered by the comp...

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Literature Corpus work: 5e16eafd-9ecd-5404-828f-d3e9c1feaf84
DOI: 10.1101/2025.01.31.635608

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