Article

Transcriptional landscape of PTEN loss in primary prostate cancer

2020-10-09

Abstract excerpt

<h4>ABSTRACT</h4> PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have not been described in detail. Here, we applied a meta-analysis approach, leveraging two large PCa cohorts with experimentally validated PTEN and ERG status, to derive a transcriptomic sign...

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Literature Corpus work: 6641392c-2541-5756-a4e6-31d20864ac7d
DOI: 10.1101/2020.10.08.332049

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