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Article

PTEN deletion drives aberrations of DNA methylome and transcriptome in different stages of prostate cancer

29 Nov 2019

Abstract excerpt

Phosphatase and tensin homolog located on chromosome 10 (PTEN) is a tumor suppressor gene and one of the most frequently mutated/deleted genes in human prostate cancer (PCa). However, how PTEN deletion would impact the epigenome and transcriptome alterations remain unknown. This hypothesis was tested in a prostate-specific PTEN-/- (KO) mouse prostatic adenocarcinoma model through DNA methyl-Seq and RNA-Seq...

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PMID: 31914691
DOI: 10.1096/fj.201901205rr

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