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Article

The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer

22 Oct 2020

Abstract excerpt

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which negatively regulates the PI3K-AKT-mTOR pathway, is strongly linked to advanced prostate cancer progression and poor clinical outcome. Accordingly, several therapeutic approaches are currently being explored to combat PTEN-deficient tumors. These include classical inhibition of the PI3K-AKT-mTOR signaling network,...

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PMID: 33105713
DOI: 10.3390/cells9112342

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