Article

TGF-β induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids

2023-04-05

Abstract excerpt

Extracellular matrix (ECM) tumorigenic alterations resulting in high matrix deposition and stiffening are hallmarks of adenocarcinomas and are collectively defined as desmoplasia . Here, we thoroughly analysed primary prostate cancer tissues obtained from numerous patients undergoing radical prostatectomy to highlight reproducible structural changes in the ECM leading to the loss of the glandular architecture. St...

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Literature Corpus work: 20c0d5b3-0d6d-566d-a4eb-a8596773469b
DOI: 10.1101/2023.04.03.534859

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