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Article

TGFβ signaling limits lineage plasticity in prostate cancer.

PLoS genetics - 1 May 2018

Hao Yi, Bjerke Glen A, Pietrzak Karolina, Melhuish Tiffany A, Han Yu, Turner Stephen D, Frierson Henry F, Wotton David

Abstract excerpt

Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP, and inactivation of the transforming growth factor (TGF) ß signaling pathway is associated with more advanced disease. We previously demonstrated that mouse models of CaP based on...

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Source

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Identifiers

PMID: 29782499
DOI: 10.1371/journal.pgen.1007409
PMCID: PMC5983872

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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