Article

Morula complementation restores fetal kidneys in xenocompatible <i>SALL1</i> null sheep

2026-07-20

Abstract excerpt

To meet the global shortage of organs, extensive genome modifications have been performed to “humanize” livestock tissues for xenotransplantation. However, residual immune rejection remains a problem, prompting alternative approaches that explore the use of animals as hosts for growing human organs. This requires genome editing to disable organogenesis in the host and embryo complementation with suitable donor cel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e10fd15-7739-5358-a9b6-1f63bce6bc0a
DOI: 10.64898/2026.07.17.739226

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Morula complementation restores fetal kidneys in xenocompatible <i>SALL1</i> null sheepDOI 10.64898/2026.07.17.739226Read

Efficient production of biallelic <i><scp>GGTA</scp>1</i> knockout pigs <i>by</i> cytoplasmic microinjection of <scp>CRISPR</scp>/Cas9 into zygotesSemantic proximity Read

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 geneSemantic proximity Read

A mouse line expressing <i>Sall1</i>‐driven inducible Cre recombinase in the kidney mesenchymeSemantic proximity Read

Testes of <i>DAZL</i> null sheep lack spermatogonia and maintain normal somatic cellsSemantic proximity Read

Novel engraftment and T cell differentiation of human hematopoietic cells in <i>Art</i> <sup>-/-</sup> <i>IL2RG</i> <sup>-/</sup> SCID pigsSemantic proximity Read

Xenotransplantation Literature Update July–December 2024Semantic proximity Read

Multi-omic profiling of paired pig liver and kidney xenografts in a human decedentSemantic proximity Read

Live pigs produced from genome edited zygotes.Semantic proximity Read

Production and Functional Verification of 8‐Gene ( GGTA1 , CMAH , β4GalNT2 , hCD46 , hCD55 , hCD59 , hTBM , hCD39 )‐Edited Donor Pigs for XenotransplantationSemantic proximity Read

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.Semantic proximity Read

Generation of cloned sheep lacking galactose-α1,3-galactose and N-glycolylneuraminic acid antigensSemantic proximity Read

Generation of α1,3-galactosyltransferase and cytidine monophospho-N-acetylneuraminic acid hydroxylase gene double-knockout pigs.Semantic proximity Read