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Article

Efficient production of biallelic <i><scp>GGTA</scp>1</i> knockout pigs <i>by</i> cytoplasmic microinjection of <scp>CRISPR</scp>/Cas9 into zygotes

1 Sept 2016

Abstract excerpt

BACKGROUND: Xenotransplantation is considered to be a promising solution to the growing demand for suitable donor organs for transplantation. Despite tremendous progress in the generation of pigs with multiple genetic modifications thought to be necessary to overcoming the severe rejection responses after pig-to-non-human primate xenotransplantation, the production of knockout pigs by somatic cell nuclear...

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PMID: 27610605
DOI: 10.1111/xen.12258

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Efficient production of biallelic <i><scp>GGTA</scp>1</i> knockout pigs <i>by</i> cytoplasmic microinjection of <scp>CRISPR</scp>/Cas9 into zygotesPMID 27610605Read ↗

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