Article

Multi-omic profiling of paired pig liver and kidney xenografts in a human decedent

2026-08-25

Abstract excerpt

<title>Abstract</title> <p>The interactions and adaptive responses of liver and kidney xenografts within the same recipient remain poorly understood. Therefore, we transplanted an auxiliary liver and a heterotopic kidney from one six-gene-edited pig into a human decedent. Longitudinal blood profiling was integrated with source-resolved single-cell transcriptomics, chromatin accessibility, spatial and proteomic an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15849360-c751-5ff3-8c62-c790382f16e5
DOI: 10.21203/rs.3.rs-10663036/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omic profiling of paired pig liver and kidney xenografts in a human decedentDOI 10.21203/rs.3.rs-10663036/v1Read

Longitudinal multi-omic profiling of a pig-to-human lung xenograft reveals phased immune and tissue-remodeling responsesSemantic proximity Read

Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism ResponsesSemantic proximity Read

Spatiotemporal immune atlas of the first clinical-grade, gene-edited pig-to-human kidney xenotransplantSemantic proximity Read

A high-resolution cell atlas of the domestic pig lung and an online platform for exploring lung single-cell data.Semantic proximity Read

Decoding Single-cell Landscape and Intercellular Crosstalk in the Transplanted LiverSemantic proximity Read

Xenotransplantation Literature Update July–December 2024Semantic proximity Read

Evaluation of Physiological Integrity in Six‐Gene‐Edited Bama Miniature Pigs as a Model for XenotransplantationSemantic proximity Read

Reduced endothelial activation upon human blood perfusion of pig kidney xenografts lacking MHC class I and three xenoantigensSemantic proximity Read

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney diseaseSemantic proximity Read

First-in-Human, Open-Label, Within-Patient Controlled Study to Evaluate an Extensively Humanized Porcine DonorSemantic proximity Read

Specific pathogen free ten gene-edited donor pigs for xenotransplantationSemantic proximity Read

Specific Pathogen Free Ten Gene-Edited Pig Donor for XenotransplantationSemantic proximity Read