Article

Generation of cloned sheep lacking galactose-α1,3-galactose and N-glycolylneuraminic acid antigens

2025-11-03

Abstract excerpt

Livestock have long been regarded as a potential source of donor organs to alleviate the global organ shortage for transplantation. Sheep have a similar physiology and anatomy to humans, providing the standard model for demonstrating biocompatibility and performance of biological heart valves to obtain regulatory approval for their use in transplantation. Like most mammals, sheep cells contain two well-characteriz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14530431-ff83-5902-869d-52b0223f57db
DOI: 10.1101/2025.10.31.684537

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of cloned sheep lacking galactose-α1,3-galactose and N-glycolylneuraminic acid antigensDOI 10.1101/2025.10.31.684537Read

Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigensSemantic proximity Read

An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native PigsSemantic proximity Read

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantationSemantic proximity Read

Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responsesSemantic proximity Read

Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2Semantic proximity Read

Antigenicity of tissues and organs from GGTA1/CMAH/β4GalNT2 triple gene knockout pigsSemantic proximity Read

Evaluation of Physiological Integrity in Six‐Gene‐Edited Bama Miniature Pigs as a Model for XenotransplantationSemantic proximity Read

Development of a BM7G((TKO/hCD46/hCD55/hTHBD/hEPCR) Donor Pig with Endogenous Promoter-Driven Transgenes for XenotransplantationSemantic proximity Read

Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9Semantic proximity Read

α1,3-Galactosyltransferase Deficiency in Germ-Free Miniature Pigs Increases N -Glycolylneuraminic Acids As the Xenoantigenic Determinant in Pig–Human XenotransplantationSemantic proximity Read

CRISPR-mediated engineering of bovine satellite cells for Alpha-Gal Syndrome-compatible cultivated meatSemantic proximity Read

Production and Functional Verification of 8‐Gene ( GGTA1 , CMAH , β4GalNT2 , hCD46 , hCD55 , hCD59 , hTBM , hCD39 )‐Edited Donor Pigs for XenotransplantationSemantic proximity Read