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Production and Functional Verification of 8‐Gene ( GGTA1 , CMAH , β4GalNT2 , hCD46 , hCD55 , hCD59 , hTBM , hCD39 )‐Edited Donor Pigs for Xenotransplantation

6 Apr 2025

Abstract excerpt

ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear. In this study, we utilised CRISPR/Cas9 gene editing technology, PiggyBac transposon system, and serial somatic cell cloning technology to develop GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/hCD59/hCD39/hTBM 8 gene‐edited cloned (GEC)...

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PMID: 40190036
DOI: 10.1111/cpr.70028

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