Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

doi:10.1073/pnas.1406376111

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Article

Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014

Lee Kiho, Kwon Deug-Nam, Ezashi Toshihiko, Choi Yun-Jung, Park Chankyu, Ericsson Aaron C, Brown Alana N, Samuel Melissa S, Park Kwang-Wook, Walters Eric M, Kim Dae Young, Kim Jae-Hwan, Franklin Craig L, Murphy Clifton N, Roberts R Michael, Prather Randall S, Kim Jin-Hoi

Abstract excerpt

Pigs with severe combined immunodeficiency (SCID) may provide useful models for regenerative medicine, xenotransplantation, and tumor development and will aid in developing therapies for human SCID patients. Using a reporter-guided transcription activator-like effector nuclease (TALEN) system, we generated targeted modifications of recombination activating gene (RAG) 2 in somatic cells at high efficiency,...

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Identifiers

PMID: 24799706
DOI: 10.1073/pnas.1406376111
PMCID: PMC4034252

Genes

RAG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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