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Article

Live pigs produced from genome edited zygotes.

Scientific reports - 10 Oct 2013

Lillico Simon G, Proudfoot Chris, Carlson Daniel F, Stverakova Dana, Neil Claire, Blain Carol, King Tim J, Ritchie William A, Tan Wenfang, Mileham Alan J, McLaren David G, Fahrenkrug Scott C, Whitelaw C Bruce A

Abstract excerpt

Transcription activator-like effector nuclease (TALEN) and zinc finger nuclease (ZFN) genome editing technology enables site directed engineering of the genome. Here we demonstrate for the first time that both TALEN and ZFN injected directly into pig zygotes can produce live genome edited pigs. Monoallelic as well as heterozygous and homozygous biallelic events were identified, significantly broadening the use of...

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Identifiers

PMID: 24108318
DOI: 10.1038/srep02847
PMCID: PMC6505673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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