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Article

Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

10 Jan 2017

Abstract excerpt

Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model of human physiology and an agriculturally important species. In this study, we utilized the CRISPR/Cas9 system to edit the NANOS2 gene in pig embryos to generate offspring with mono-allelic and bi-allelic mutations. We found that NANOS2 knockout pigs...

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PMID: 28071690
DOI: 10.1038/srep40176

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