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Involvement of Cyclin Dependent Kinase 5 in M4 Muscarinic Acetylcholine Receptor-Mediated Cholinergic Transmission within the Mouse Dorsal Striatum

2021-03-13

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>An imbalance between dopamine (DA) and acetylcholine (ACh) within the striatum has reemerged as key to the pathophysiology of the neurodegenerative disorder, Parkinson's disease (PD). M<sub>4</sub> is a prominent muscarinic ACh receptor subtype in the striatum and we have previously reported that M<sub>4</sub> controls cyclin-dependent kinase 5 (Cdk5) / dopamine...

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Literature Corpus work
5df93b69-094e-52a5-880e-f0b886213182
DOI
10.21203/rs.3.rs-290339/v1
Open publication

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Involvement of Cyclin Dependent Kinase 5 in M4 Muscarinic Acetylcholine Receptor-Mediated Cholinergic&nbsp;Transmission within the Mouse Dorsal StriatumDOI 10.21203/rs.3.rs-290339/v1
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