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Article

Cdk5 induces constitutive activation of 5-HT6 receptors to promote neurite growth.

Nature chemical biology - 1 Jul 2014

Duhr Fanny, Déléris Paul, Raynaud Fabrice, Séveno Martial, Morisset-Lopez Séverine, Mannoury la Cour Clotilde, Millan Mark J, Bockaert Joël, Marin Philippe, Chaumont-Dubel Séverine

Abstract excerpt

The serotonin6 receptor (5-HT6R) is a promising target for treating cognitive deficits of schizophrenia often linked to alterations of neuronal development. This receptor controls neurodevelopmental processes, but the signaling mechanisms involved remain poorly understood. Using a proteomic strategy, we show that 5-HT6Rs constitutively interact with cyclin-dependent kinase 5 (Cdk5). Expression of 5-HT6Rs in...

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PMID: 24880860
DOI: 10.1038/nchembio.1547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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