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Discovery of the first selective M <sub>4</sub> muscarinic acetylcholine receptor antagonists with <i>in vivo</i> anti-parkinsonian and anti-dystonic efficacy

2020-10-12

Abstract excerpt

Non-selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson disease and dystonia. Despite their efficacy in these and other central nervous system disorders, anti-muscarinic therapy has limited utility due to severe adverse effects that often limit their tolerability by patien...

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Literature Corpus work
06b7b611-e823-5b90-8b1f-b961b2443ceb
DOI
10.1101/2020.10.12.324152
Open publication

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Discovery of the first selective M <sub>4</sub> muscarinic acetylcholine receptor antagonists with <i>in vivo</i> anti-parkinsonian and anti-dystonic efficacyDOI 10.1101/2020.10.12.324152
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