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Article

Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

14 Jun 2022

Abstract excerpt

Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment and Parkinson's disease (PD)-related circadian perturbations that may represent an early prodromal marker of PD. Cyclin-dependent kinase 5 (CDK5) negatively regulates dopamine signaling in the striatum, suggesting a critical role of CDK5 in circadian and sleep disorders. Here, we used clustered regularly interspaced short...

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PMID: 35701839
DOI: 10.1186/s13041-022-00939-2

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