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Article

Downregulation of CDK5 Signaling In the Dorsal Striatum Alters Striatal Microcircuits and Perturbs Circadian Behavior in Mice

2021-12-30

Abstract excerpt

<title>Abstract</title> <p>Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment as well as in Parkinson’s disease (PD)-related circadian perturbations that may represent an early prodromal marker of PD. Cyclin-dependent kinase 5 (CDK5) acts negatively on dopamine (DA) signaling in the striatum, suggesting a critical role in circadian and sleep disorders. Here, we used CRISPR/Cas9...

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Literature Corpus work
aa0ee92e-e3fb-5652-9139-f97c681f5480
DOI
10.21203/rs.3.rs-1183888/v1
Open publication

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Downregulation of CDK5 Signaling In the Dorsal Striatum Alters Striatal Microcircuits and Perturbs Circadian Behavior in MiceDOI 10.21203/rs.3.rs-1183888/v1
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