Article

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy

2023-08-17

Abstract excerpt

<title>Abstract</title> <p>Parkinson's disease (PD) is a debilitating neurodegenerative disease characterized by the loss of midbrain dopaminergic neurons (DaNs) and the abnormal accumulation of α-Synuclein (α-Syn) protein. Currently, no treatment can slow nor halt the progression of PD. Multiplications and mutations of the α-Syn gene (SNCA) cause PD-associated syndromes and animal models that overexpress α-Syn r...

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Literature Corpus work: aa096de6-c6f1-5d49-91ec-6e766a3d34ae
DOI: 10.21203/rs.3.rs-3182457/v1

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