Article

Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models

2019-07-02

Abstract excerpt

Cyclin-dependent-like kinase 5 ( Cdkl5) gene mutations lead to an X-linked disorder that is characterized by infantile epileptic encephalopathy, developmental delay and hypotonia. However, we found that a substantial percentage of these patients also report a previously unrecognised anamnestic deficiency in pain perception. Consistent with a role in nociception, we discovered that Cdkl5 is expressed selectively i...

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Literature Corpus work: 070fb29c-d663-52d6-910b-56d5b77a1cee
DOI: 10.1101/690172

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