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Article

Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.

Biological psychiatry - 15 Dec 2010

Drerup Justin M, Hayashi Kanehiro, Cui Huxing, Mettlach Gabriel L, Long Michael A, Marvin Marian, Sun Xiankai, Goldberg Matthew S, Lutter Michael, Bibb James A

Abstract excerpt

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) may result from delayed establishment of corticolimbic circuitry or perturbed dopamine (DA) neurotransmission. Despite the widespread use of stimulants to treat ADHD, little is known regarding their long-term effects on neurotransmitter levels and metabolism. Cyclin-dependent kinase 5 (Cdk5) regulates DA signaling through control of synthesis,...

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Source

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Identifiers

PMID: 20832057
DOI: 10.1016/j.biopsych.2010.07.016
PMCID: PMC2997929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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