Article

EphA4 regulates Aβ production via BACE1 expression in neurons

2020-06-03

Abstract excerpt

<title>Abstract</title> <p>BackgroundSeveral lines of evidence suggest that the aggregation and deposition of amyloid-β peptide (Aβ) initiate the pathology of Alzheimer disease (AD). Recently, a genome- wide association study demonstrated that a single-nucleotide polymorphism proximal to the <italic>EPHA4 </italic>gene, which encodes a receptor tyrosine kinase, is associated with AD risk. However, the molecular m...

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Literature Corpus work: 3310ba5b-42fe-5719-aba5-39765fa29df1
DOI: 10.21203/rs.3.rs-32033/v1

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