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Circulating exosomes from Alzheimer’s disease suppress VE-cadherin expression and induce barrier dysfunction in recipient brain microvascular endothelial cell

2023-04-06

Abstract excerpt

<h4>Background</h4> Blood-brain barrier (BBB) breakdown is a component of the progression and pathology of Alzheimer’s disease (AD). BBB dysfunction is primarily caused by reduced or disorganized tight junction or adherens junction proteins of brain microvascular endothelial cell (BMEC). While there is growing evidence of tight junction disruption in BMECs in AD, the functional role of adherens junctions during B...

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Literature Corpus work
14e32c8f-6ea7-5e53-b55f-4a81922f20ee
DOI
10.1101/2023.04.03.535441
Open publication

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Circulating exosomes from Alzheimer’s disease suppress VE-cadherin expression and induce barrier dysfunction in recipient brain microvascular endothelial cellDOI 10.1101/2023.04.03.535441
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