Article

Efficient Derivation of Immortalized, Isogenic Cell Lines from Genetically Defined Murine Hepatoblastomas

2024-10-01

Abstract excerpt

<h4>Background & Aims</h4> Molecularly, hepatoblastoma (HB), the most common childhood liver cancer, is the simplest of all human neoplasms, with the vast majority deregulating the Wnt/β-catenin, Hippo and/or NFE2/NRF2 signaling pathways. Murine HBs can be generated by over-expressing any pairwise or triple combination of mutant forms of these pathways’ terminal effectors, namely β-catenin (B), YAP (Y) and NFE2L2...

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Literature Corpus work: 5db6a2bc-2df2-5721-81ee-7b7e9abddce3
DOI: 10.1101/2024.09.29.615692

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