Article

Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas

2020-09-13

Abstract excerpt

<h4>Background and Aims</h4> Hepatoblastoma (HB), the most common pediatric liver cancer, often bears β-catenin mutations and deregulates the Hippo tumor suppressor pathway. Murine HBs can be generated by co-expressing β-catenin mutants and the constitutively active Hippo effector YAP S127A . Some HBs and other cancers also express mutants of NFE2L2/NRF2 (NFE2L2), a transcription factor that tempers oxidative an...

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Literature Corpus work: bbb923aa-617c-5808-abf9-6e4f8d39dcae
DOI: 10.1101/2020.09.13.295311

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