Article

Cholangiocytic differentiation drives cell proliferation in hepatoblastoma through Wnt-dependent FGF19 signaling

2023-06-08

Abstract excerpt

<h4>SUMMARY</h4> Cancers evolve not only through the acquisition and clonal transmission of somatic mutations but also by non-genetic mechanisms that modify cell phenotype. Here, we describe how transcriptional heterogeneity arises within human hepatoblastoma, one of the cancers with the lowest mutational burden, characterized by activating mutations in the Wnt pathway. Histology-guided RNA sequencing and evaluat...

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Literature Corpus work: 22951284-7e13-58e4-821b-f1c2225d30e4
DOI: 10.1101/2023.06.08.544267

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