Article

Gas1-Mediated Suppression of Hepatoblastoma Tumorigenesis

2024-10-03

Abstract excerpt

<h4>Background and Aims</h4> Hepatoblastoma (HB), the most common pediatric liver cancer, often dysregulates the Wnt/β-catenin, Hippo and NFE2L2/NRF2 pathways. Pairwise combinations of oncogenically active forms of the terminal transcription factor effectors of these pathways, namely β-catenin (B), YAP (Y) and NRF2 (N) generate HBs in mice, with the triple combination (B+Y+N) being particularly potent. Each tumor...

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Literature Corpus work: 49476768-8e45-57eb-a161-99bdb953462e
DOI: 10.1101/2024.10.02.616350

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