Article

Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform

2022-02-01

Abstract excerpt

<title>Abstract</title> <p>Lung cancer is the leading cause of cancer-related death worldwide. Lung adenocarcinoma (LUAD), the most common histological subtype, accounts for 40% of all cases. While autochthonous, genetically engineered mouse models (GEMMs) recapitulate the histological progression and transcriptional evolution of human LUAD, tumors in these models develop over several months and functional genomi...

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Literature Corpus work: 4bf35ec3-9571-5e9b-a46f-fa72425fdfa5
DOI: 10.21203/rs.3.rs-1281542/v1

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