Article
HepT1-derived murine models of high-risk hepatoblastoma display vascular invasion, metastasis, and circulating tumor cells
2021-07-10
Abstract excerpt
Hepatoblastoma (HB) is the most common pediatric primary liver malignancy, and survival for high-risk disease approaches 50%. Mouse models of HB fail to recapitulate hallmarks of high-risk disease. The aim of this work was to generate murine models that show high-risk features including multifocal tumors, vascular invasion, metastasis, and circulating tumor cells (CTCs). HepT1 cells were injected into the livers o...
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Identifiers and source
- Literature Corpus work
- d4bca85d-85b4-5444-84d3-9601054870b7
- DOI
- 10.1101/2021.07.09.451809