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Synthetic Lethality in Cancer Therapeutics: The Next Generation

1 Apr 2021

Abstract excerpt

Synthetic lethality (SL) provides a conceptual framework for tackling targets that are not classically "druggable," including loss-of-function mutations in tumor suppressor genes required for carcinogenesis. Recent technological advances have led to an inflection point in our understanding of genetic interaction networks and ability to identify a wide array of novel SL drug targets. Here, we review concepts and...

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PMID: 33795234
DOI: 10.1158/2159-8290.cd-20-1503

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