Article

ELISL: Early-Late Integrated Synthetic Lethality Prediction in Cancer

2022-09-19

Abstract excerpt

Anti-cancer therapies based on synthetic lethality (SL) exploit tumor vulnerabilities for treatment with reduced side effects. Since simultaneous loss-of-function of SL genes causes cell death, tumors with known gene disruptions can be treated by targeting SL partners. Computational selection of promising SL candidates amongst all gene combinations is key to expedite experimental screening. However, current SL pre...

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Literature Corpus work: a35d7faa-13b8-5212-b510-235bfca26c4c
DOI: 10.1101/2022.09.19.508413

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