Article

Cell division history encodes directional information of fate transitions

2022-10-07

Abstract excerpt

Single-cell RNA-sequencing (scRNA-seq) enables systematic mapping of cellular differentiation trajectories. However, inferring the cell-fate transitions under diseases or perturbations is still challenging due to the high cellular plasticity. Here, we demonstrate that monotonically expressed genes (MEGs) along cell divisions record the directions of state transitions regardless of the cellular processes. We develo...

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Literature Corpus work: 0b90325e-0ebf-54fe-86eb-8cde2290771f
DOI: 10.1101/2022.10.06.511094

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