Article

Building dynamical models of multi-step state transitions from single cell gene expression trajectories

2025-12-11

Abstract excerpt

Multi-step cell state transitions often occur in biological processes, such as cell differentiation and disease progression, yet the regulatory mechanisms governing these transitions remain unclear. Here, we introduce NetDes, a computational method that integrates top-down and bottom-up systems biology to infer core transcription factor regulatory networks and build ODE-based dynamical models from single-cell gene...

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Literature Corpus work: 4c282aa3-86e9-5cc8-8ab7-c0289fc55e08
DOI: 10.64898/2025.12.08.693064

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