Article

Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation

2025-05-27

Abstract excerpt

Vascular smooth muscle cells (VSMCs) contribute dynamically to atherosclerosis at all stages but the molecular drivers of their phenotypic switching, especially during early plaque development, and how they contribute to plaque progression remain unclear. We performed spatial transcriptomics on 12 human aortic tissues with and without atherosclerotic plaque. Macrophage-like SMCs were the predominant cell-type in t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d694f60-46e5-54f6-b378-fd3cfb804360
DOI: 10.1101/2025.05.22.655434

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulationDOI 10.1101/2025.05.22.655434Read

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteriesSemantic proximity Read

Molecular and spatiotemporal characterization of cells in murine atherosclerotic plaquesSemantic proximity Read

Stage-resolved Spatial Multi-omics Reveals Myeloid Niches in Human Atherosclerotic PlaquesSemantic proximity Read

Trimethylamine-N-oxide affects cell type-specific pathways and networks in mouse aorta to promote atherosclerotic plaque vulnerabilitySemantic proximity Read

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment.Semantic proximity Read

Modulated smooth muscle cells accumulate late in human coronary atherosclerosis and are temporally and spatially linked to necrotic core formationSemantic proximity Read

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.Semantic proximity Read

Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic ModulationSemantic proximity Read

Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in AtherosclerosisSemantic proximity Read

Encompassing view of spatial and single-cell RNA-seq renews the role of the microvasculature in human atherosclerosisSemantic proximity Read

Transcriptomic, Specific Marker, and Pathway Analysis of Smooth Muscle Cell Foam Cells Relative to Macrophage Foam Cells in Human AtherosclerosisSemantic proximity Read

Deciphering Macrophage Phenotypes upon Lipid Uptake and AtherosclerosisSemantic proximity Read