Article

Fluoxetine rescues rotarod motor deficits in <i>Mecp2</i> heterozygous mouse model of Rett syndrome via brain serotonin

2020-06-12

Abstract excerpt

Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 ( MECP2 ) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RTT patients and Mecp2 mutant mice, regulates motor circuits and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d5bfdeb-5338-5a05-ac93-d6cf2fcb55b5
DOI: 10.1101/2020.06.12.147876

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fluoxetine rescues rotarod motor deficits in <i>Mecp2</i> heterozygous mouse model of Rett syndrome via brain serotoninDOI 10.1101/2020.06.12.147876Read

5-HT1A Receptor Agonist Treatment Partially Ameliorates Rett Syndrome Phenotypes in mecp2-Null Mice by Rescuing Impairment of Neuron Transmission and the CREB/BDNF Signaling Pathway.Semantic proximity Read

Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes.Semantic proximity Read

Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes during developmentSemantic proximity Read

Rett syndrome treatment in mouse models: searching for effective targets and strategies.Semantic proximity Read

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome miceSemantic proximity Read

Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor.Semantic proximity Read

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.Semantic proximity Read

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice.Semantic proximity Read

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches.Semantic proximity Read

MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome.Semantic proximity Read

Leptin antagonism improves Rett syndrome phenotype in symptomatic <i>Mecp2-</i> deficient miceSemantic proximity Read

Evaluation of current pharmacological treatment options in the management of Rett syndrome: from the present to future therapeutic alternatives.Semantic proximity Read