Article

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice

2023-11-12

Abstract excerpt

<h4>SUMMARY</h4> Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 ( MECP2 ), encoding a transcriptional regulator of many genes, including brain-derived neurotrophic factor ( Bdnf ). BDNF mRNA and protein levels are lower in RTT autopsy brains and in multiple brain regions of Mecp2 -deficient mice, and experimentally increasing BDNF levels improve atypica...

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Literature Corpus work: 0e2bc8fa-7c35-50b3-bb67-68ec18aaa36f
DOI: 10.1101/2023.11.09.566435

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